PROFIL NEUTROPHIL-TO-LYMPHOCYTE RATIO PADA DEMAM TIFOID

Abstrak

Typhoid fever is an acute or chronic systemic infectious disease caused by the gram-negative bacteria Salmonella typhi. WHO stated that the incidence of typhoid fever reached 21 million cases with a mortality rate of 161,000 in Southeast Asia and South Asia. Cases of typhoid fever can be fatal due to low awareness and inadequate treatment, so adequate examination or diagnostic support is needed. Typhoid fever has typical hematological abnormalities, namely anemia, leukopenia, eosinophilia, thrombocytopenia and subclinical disseminated intravascular coagulation. Typhoid fever can affect the hematopoietic system including neutrophils and lymphocytes. Neutropenia is a clinical picture that is often found in cases of typhoid fever. This hematological picture can be used as a tool to aid diagnosis and management of the patient's condition appropriately. NLR is thought to have high diagnostic and better sensitivity than CRP as a marker of sepsis. The aim of this research is to obtain an overview of the results of calculating the number of neutrophils, lymphocytes and NLR. Descriptive survey research design with a large sample using the purposive sampling method. The number of neutrophils and lymphocytes was measured using a Sysmex XN-450 hematology analyzer. The mean neutrophil count was 59.98, the lymphocyte count was 32.36, and the mean NLR value was 2.74. NLR can be used as a marker of inflammation but requires other supporting examinations