CLINICAL AND ECONOMIC IMPACT OF INFECTION Methicillin-resistant Staphylococcus aureus (MRSA) BACTERIAL INFECTION AT GUNUNG JATI GENERAL HOSPITAL, CIREBON CITY

Abstrak

Methicillin-resistant Staphylococcus aureus (MRSA) infection is a significant clinical and economic problem in hospitals. This study analyzed the clinical and economic impact of MRSA infection compared to Methicillin-susceptible Staphylococcus aureus (MSSA) infection at Gunung Jati Regional Hospital, Cirebon. An analytical cross-sectional study was conducted on 178 patients screened for MRSA from Januari 2021 to December 2024. Results showed that 33.14% of patients were infected with MRSA and 66.85% with MSSA. The majority if MRSA patients were female (59.3%) and aged 25-64 yeras (50.8%). The dominant diagnosis was sepsis (42.4%), with comorbid diabetes mellitus being higher in MRSA (55.9%) than in MSSA (33.6%). Bivariate analysis showed that MRSA had a mean length of stay of 7 days, longer than MSSA (4 days) (p=0.004). Mortality in MRSA patients was significantly higher (45.8%) than in MSSA (21.0%), with an odds rasio of 3.17 (95% CI: 1.61-6.25, p=0.001). The costs of treatment, care and laboratoty tests in MRSA were also higher, averaging Rp 325,793.20 compared to Rp 129,089.49 in MSSA. These findings confirm that MRSA infections are associated with higher clinical severity, longer hospital stays, higher mortality, and a significant economic burden compared to MSSA. Prevention and management of MRSA infections should be improved to reduce the negative impact on healthcare facilities.